Numerous studies have confirmed the presence of an inverse relationship between serum thyroxin and cholesterol levels. Furthermore, the thyroid hormones play an important role in regulating lipid metabolism. Existing evidence has demonstrated that the relationship of TSH and lipid levels was different between overweight and normal weight populations and between men and women. The differences in the studies have been ascribed to the influence of some confounding factors, such as age, gender and body mass index (BMI). A series of studies reported that a high level of TSH was associated with a deleterious change of serum lipids, with an increase of lipid abnormalities however, this issue has been the subject of considerable debate, and several studies have not observed such an association. Elevated TSH levels have recently aroused interest due to the potential for TSH to induce injury, especially in patients with coronary heart disease (CHD). Moreover, similar consequences were found for subclinical hypothyroidism (SCH), which is characterized by elevated serum thyroid stimulating hormone (TSH) levels and normal thyroxine (T4) levels. Abnormal thyroid hormone metabolism may lead to different forms of heart disease and hypothyroidism, in particular, is a well-known cause of accelerated coronary atherosclerosis. The thyroid hormones exert a wide range of functions in several organs, including the heart. The present study suggests a potential physiological role of TSH and the importance of maintaining an appropriate TSH level in CHD patients. TSH can increase the TC level in CHD patients independent of TH. Each 1 mIU/L increase in the TSH level might be linked to a 0.015580712 mmol/L elevation of the serum TC value. Even after adjusting for confounding factors, such as sex, age, smoking status, fasting plasma glucose levels and TH, a significant positive impact of TSH on the serum total cholesterol (TC) level was revealed (r = 0.095, p = 0.036). The prevalence of thyroid dysfunction among the patients was 18.66%, and the prevalence of hypothyroidism (15.32%) was higher than that of hyperthyroidism (3.34%). ResultsĪfter the exclusions, a total of 568 patients (270 males and 298 females with a mean age of 63.56 ± 11.376 years) were selected. To calculate the extent of the effect of TSH on the serum cholesterol level, the partial least squares method and additional statistical methods were used. To assess the impact of TSH on serum lipids, Pearson’s correlation analysis was performed after adjustments for classic factors and TH. The prevalence and distribution of thyroid dysfunction were analyzed first. Methodsġ302 CHD patients diagnosed by coronary angiography were retrospectively studied. The aim of the present study was to evaluate the relationship between serum TSH levels and the lipid profile independent of TH. The relationship between TSH and the lipid profile is contradictory because few studies have excluded the potential influence of the thyroid hormones (TH).
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